Pharmacology: Pharmacokinetics: Distribution of chlorphenamine into human body tissues and fluids has not been fully characterized. Following IV administration in rabbits, highest concentration of the drug is attained in the lungs, heart, kidneys, brains, small intestine and spleen with lower concentrations in the large intestine, muscle, stomach, adrenal fat, liver and mesentery. Following IV administration in humans, chlorphenamine undergoes rapid and extensive distribution. Chlorphenamine is distributed into saliva and the drug and/or its metabolites appear to be distributed in small amounts into bile. Chlorphenamine and its metabolites are excreted almost completely in urine. Excretion is dependent on urinary pH and flow rate. Only trace amounts have been found in the faeces. More rapid and extensive absorption, faster clearance and a shorter half-life have been reported in children.
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